I propose the following variants:
1) Genetically engineered creatures, that broke away from some laboratory. The creatures were created as a part of experiment to make artificial servants. Maybe they even were mass produced and distributed in cities, then one day they rebelled and wiped out majority of humans. This can explain the catastroph that brought down civilization. Or some other catastroph destroyed civilization first and creatures became wild in a years when no humans controled them. The creatures are humanoid in form with low intelligence, but capable of making and using primitive weapons and tools. Can look like neanderthals or something similar. Live in tribes and are extremely hostile towards humans. Creatures tribes live in caves, abandoned mines or cities ruins. Some hunt and scout in countryside where players are.
2) Alien nonsentient crearures.
The creatures spores or larvas were brought on Earth with a meteorite. The alien creatures are collective swarm creatures, like zergs. But they shouldn't be all the size of a man, only soldires. They can be insectlike or like creatures from Lost Planet. They evolve and adapt rapidly and there are many types of them, like ants sociobiological types: larvas, workers, soldiers, queens and others. Workers collect food and/or materials, soldires come to protect them and guard nests. These creatures can be use to explain the catastroph as well.
3) Robotic weapons like the one in the movie "Screamers": autonomous mobile swords.
http://5wordmoviereviews.files.wordp...mers_type1.jpg
http://grizzlybomb.com/wp-content/up..._technisch.jpg
http://p2.la-img.com/930/18669/6321634_1_l.jpg
Not humanoid like but something simular to ones on pictures above. It can be not only swords but mines also. And some spider like robots with cutters as well.
These robots were developed instead of mines to be used in a future war. Either they were spread out by some enemy nation, or went out of control as a consequence of the catastroph, that destroyed civilization or they themselves are the cause of the catastroph, but now they plague the area.
4) Humans who are controlled by parasite alien puppeteers, that are attached to their backs.
Once the infested person is killed the parasite tries to jump on the player and turn him into its host.
The parasites have relatively low intelligence so their hosts can't use or produce advanced weapons, only melee ones.

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